Zeyun Yu and Chandrajit Bajaj, "Visualization of Icosahedral Virus
Structures from Reconstructed Volumetric Maps", The University of Texas at
Austin, Department of Computer Sciences, Technical Report TR-04-10, April
9, 2004.

Abstract:
In this paper we present an automatic algorithm to segment the
asymmetric subunits of an icosahedral density map. This approach
is readily applicable to the structural analysis of a broad range
of macromolecular structures that are reconstructed using the
cryo-electron microscopy (cryoEM) technique. Our algorithm
includes three major steps: the detection of critical points, the
detection of icosahedral symmetry axes, and the segmentation of
asymmetric subunits. The experiments on the real molecular density
maps reconstructed by cryoEM technique as well as the synthetic
maps calculated from the Protein Data Bank (PDB) demonstrate the
high-quality performance of our approach.